Viral Reservoir in Early-Treated Human Immunodeficiency Virus-Infected Children and Markers for Sustained Viral Suppression.

ABSTRACT:

Background

The impact of very early infant treatment on human immunodeficiency virus (HIV) reservoir, and markers for treatment success, require study.

Methods

The Early Infant Treatment Study (EIT) enrolled 40 children living with HIV started on antiretroviral treatment (ART) at <7 days of age, with 23 who had started treatment between 30-365 days to serve as controls. Quantitative HIV DNA was evaluated every 1-3 months in peripheral blood mononuclear cells. 84-week repeat qualitative whole blood DNA polymerase chain reaction and dual enzyme immunosorbent assay were performed.

Results

Median quantitative cell-associated DNA after at least 84 weeks was significantly lower among the first 27 EIT children tested than among 10 controls (40.8 vs 981.4 copies/million cells

SUBMITTER: Ajibola G 

PROVIDER: S-EPMC8366827 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature