MeCP2 mediates transgenerational transmission of chronic pain.

ABSTRACT: Pain symptoms can be transmitted across generations, but the mechanisms underlying these outcomes remain poorly understood. Here, we identified an essential role for primary somatosensory cortical (S1) glutamate neuronal DNA methyl-CpG binding protein 2 (MeCP2) in the transgenerational transmission of pain. In a female mouse chronic pain model, the offspring displayed significant pain sensitization. In these mice, MeCP2 expression was increased in S1 glutamate (Glu^S1) neurons, correlating with increased neuronal activity. Downregulation of Glu^S1 neuronal MeCP2 in maternal mice with pain abolished offspring pain sensitization, whereas overexpression of MeCP2 in naïve maternal mice induced pain sensitization in offspring. Notably, single-cell sequencing and chromatin im

SUBMITTER: Tao W 

PROVIDER: S-EPMC8367090 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature