A retroviral insertion in the tyrosinase (TYR) gene is associated with the recessive white plumage color in the Yeonsan Ogye chicken.

ABSTRACT: The recessive white (locus c) phenotype observed in chickens is associated with three alleles (recessive white c, albino c^a , and red-eyed white c^re ) and causative mutations in the tyrosinase (TYR) gene. The recessive white mutation (c) inhibits the transcription of TYR exon 5 due to a retroviral sequence insertion in intron 4. In this study, we genotyped and sequenced the insertion in TYR intron 4 to identify the mutation causing the unusual white plumage of Yeonsan Ogye chickens, which normally have black plumage. The white chickens had a homozygous recessive white genotype that matched the sequence of the recessive white type, and the inserted sequence exhibited 98% identity with the avian leukosis virus e

SUBMITTER: Cho E 

PROVIDER: S-EPMC8367395 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature