MTT and Blood-Brain Barrier Disruption within Asymptomatic Vascular WM Lesions.

ABSTRACT:

Background and purpose

White matter lesions of presumed ischemic origin are associated with progressive cognitive impairment and impaired BBB function. Studying the longitudinal effects of white matter lesion biomarkers that measure changes in perfusion and BBB patency within white matter lesions is required for long-term studies of lesion progression. We studied perfusion and BBB disruption within white matter lesions in asymptomatic subjects.

Materials and methods

Anatomic imaging was followed by consecutive dynamic contrast-enhanced and DSC imaging. White matter lesions in 21 asymptomatic individuals were determined using a Subject-Specific Sparse Dictionary Learning algorithm with manual correction. Perfusion-related parameters including CBF, MTT, the BBB leakage paramet

SUBMITTER: Dewey BE 

PROVIDER: S-EPMC8367617 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature