A time-course Raman spectroscopic analysis of spontaneous in vitro microcalcifications in a breast cancer cell line.

ABSTRACT: Microcalcifications are early markers of breast cancer and can provide valuable prognostic information to support clinical decision-making. Current detection of calcifications in breast tissue is based on X-ray mammography, which involves the use of ionizing radiation with potentially detrimental effects, or MRI scans, which have limited spatial resolution. Additionally, these techniques are not capable of discriminating between microcalcifications from benign and malignant lesions. Several studies show that vibrational spectroscopic techniques are capable of discriminating and classifying breast lesions, with a pathology grade based on the chemical composition of the microcalcifications. However, the occurrence of microcalcifications in the breast and the underlying mineralization process

SUBMITTER: Bouzy P 

PROVIDER: S-EPMC8367820 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature