Alternative activation of macrophages by prostacyclin synthase ameliorates alcohol induced liver injury.

ABSTRACT: Alcoholic liver disease (ALD) is a major cause of chronic liver disease worldwide. Macrophages exhibit different functional states and are classified as classically activated (M1) and alternatively activated (M2) macrophages. However, the mechanisms that govern M1/M2 polarization in chronic ALD remain to be elucidated. Prostacyclin (PGI₂) synthase (PTGIS) is an enzyme of the prostaglandin pathway which catalyzes the conversion of Prostaglandin H₂ (PGH₂) to PGI₂. PTGIS has anti-inflammatory properties. However, the function of PTGIS in ALD has not yet been determined. In this study, we demonstrated that PTGIS was downregulated in ALD and forced PTGIS expression in vivo using recombinant adeno-associated viral vector-packed PTGIS overexpression pla

SUBMITTER: Pan XY 

PROVIDER: S-EPMC8367821 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature