Digital Image Disintegration Analysis: a Novel Quality Control Method for Fast Disintegrating Tablets.

ABSTRACT: Measuring tablet disintegration is essential for quality control purposes; however, no established method adequately accounts for the timeframe or small volumes of the medium associated with the dissipation process for fast disintegrating tablets (FDTs) in the mouth. We hypothesised that digital imaging to measure disintegration in a low volume of the medium might discriminate between different types of FTD formulation. A digital image disintegration analysis (DIDA) was designed to measure tablet disintegration in 0.05-0.7 mL of medium. A temperature-controlled black vessel was 3D-printed to match the dimensions of each tablet under investigation. An overhead camera recorded the mean grey value of the tablet as a measure of the percentage of the formulation which remained intact as a funct

SUBMITTER: Malallah O 

PROVIDER: S-EPMC8367883 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature