The effectiveness of antiepileptic drug treatment in glioma patients: lamotrigine versus lacosamide.

ABSTRACT:

Purpose

Optimal treatment with antiepileptic drugs (AEDs) is an important part of care for brain tumor patients with epileptic seizures. Lamotrigine and lacosamide are both examples of frequently used non-enzyme inducing AEDs with limited to no drug-drug interactions, reducing the risk of unfavorable side effects. This study aimed to compare the effectiveness of lamotrigine versus lacosamide.

Methods

In this multicenter study we retrospectively analyzed data of patients with diffuse grade 2-4 glioma with epileptic seizures. All patients received either lamotrigine or lacosamide during the course of their disease after treatment failure of first-line monotherapy with levetiracetam or valproic acid. Primary outcome was the cumulative incidence of treatment failure, from initia

SUBMITTER: van Opijnen MP 

PROVIDER: S-EPMC8367894 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature