Retrospective analysis of predictive factors for lymph node metastasis in superficial esophageal squamous cell carcinoma.

ABSTRACT: This study aimed to identify the risk factors of lymph node metastasis (LNM) in superficial esophageal squamous cell carcinoma and use these factors to establish a prediction model. We retrospectively analyzed the data from training set (n = 280) and validation set (n = 240) underwent radical esophagectomy between March 2005 and April 2018. Our results of univariate and multivariate analyses showed that tumor size, tumor invasion depth, tumor differentiation and lymphovascular invasion were significantly correlated with LNM. Incorporating these 4 variables above, model A achieved AUC of 0.765 and 0.770 in predicting LNM in the training and validation sets, respectively. Adding macroscopic type to the model A did not appreciably change the AUC but led to statistically significant improvemen

SUBMITTER: Ruan R 

PROVIDER: S-EPMC8368005 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature