A bidirectional relationship between anxiety, depression and gastrointestinal symptoms in Parkinson's disease.

ABSTRACT:

Introduction

Anxiety, depression and gastrointestinal (GI) symptoms are common non-motor symptoms in Parkinson's disease (PD). Past studies provide evidence of a disrupted microbiome-gut-brain axis in PD, which is associated with certain motor and non-motor symptoms in PD. Additionally, there is evidence of a bidirectional association between mental health and gut health among individuals with GI disorders. The current study examined the bidirectional association between GI symptoms and anxiety/depression among individuals newly diagnosed with PD.

Methods

We conducted a secondary data analysis of the Parkinson's Progression Markers Initiative. This included 487 individuals newly diagnosed with PD and followed for up to 5 years. Participants completed questionnaires of anxiet

SUBMITTER: Jones JD 

PROVIDER: S-EPMC8368023 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature