The risk of contralateral breast cancer: a SEER-based analysis.

ABSTRACT:

Background

We sought to estimate the annual risk and 25-year cumulative risk of contralateral breast cancer among women with stage 0-III unilateral breast cancer.

Methods

We identified 812,851 women with unilateral breast cancer diagnosed between 1990 and 2015 in the SEER database and followed them for contralateral breast cancer for up to 25 years. Women with a known bilateral mastectomy were excluded. We calculated the annual risk of contralateral breast cancer by age at diagnosis, by time since diagnosis and by current age. We compared risks by ductal carcinoma in situ (DCIS) versus invasive disease, by race and by oestrogen receptor (ER) status of the first cancer.

Results

There were 25,958 cases of contralateral invasive breast cancer diagnosed (3.2% of all patie

SUBMITTER: Giannakeas V 

PROVIDER: S-EPMC8368197 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature