Sequential targeting of PI3Kδ and LAG3 as an effective anti-cancer approach.
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ABSTRACT:
SUBMITTER: Lauder SN
PROVIDER: S-EPMC8368216 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Publications
Sequential targeting of PI3Kδ and LAG3 as an effective anti-cancer approach.
Lauder Sarah N SN Vanhaesebroeck Bart B Gallimore Awen A
British journal of cancer 20210406 4
Emerging studies have demonstrated the potential of PI3Kδ blockade as an immunotherapy for solid tumours. In pre-clinical models, we recently demonstrated that anti-LAG3 immune checkpoint blockade vastly potentiated PI3Kδ-based immunotherapy, enabling successful tumour control in all treated mice. ...[more]
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