Performance Comparison of Five SARS-CoV-2 Antibody Assays for Seroprevalence Studies.

ABSTRACT:

Background

Seroprevalence studies of coronavirus disease 2019 (COVID-19) cases, including asymptomatic and past infections, are important to estimate the scale of the disease outbreak and to establish quarantine measures. We evaluated the clinical performance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody assays available in Korea for use in seroprevalence studies.

Methods

The sensitivity, specificity, cross-reactivity, and interference of five SARS-CoV-2 antibody assays were evaluated using the following: 398 serum samples from confirmed COVID-19 patients, 510 negative control samples from before 2018 (pre-pandemic), 163 serum samples from patients with SARS, Middle East respiratory syndrome (MERS), and other viral infections, and five samples for

SUBMITTER: Park Y 

PROVIDER: S-EPMC8368235 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature