Urine metabolic phenotyping in children with nocturnal enuresis and comorbid neurobehavioral disorders.

ABSTRACT: Nocturnal enuresis (NE) is a common problem among 10% school-aged children. The etiologies underlying childhood NE is complex and not fully understood nowadays. Nevertheless, increasing evidence suggests a potential link between neurobehavioral disorders and enuresis in children. In this study, we aimed to explore novel metabolomic insights into the pathophysiology of NE and also, its association with pediatric psychiatric problems. Urine collected from 41 bedwetting children and 27 healthy control children was analyzed by using ¹H-nuclear magnetic resonance spectroscopy from August 2017 to December 2018. At regular follow-up, there were 14 children with refractory NE having a diagnosis of attention deficient hyperactivity disorder (ADHD) or anxiety. Eventually, we identified ei

SUBMITTER: Yu MC 

PROVIDER: S-EPMC8368245 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature