Unknown

Dataset Information

0

Predicting drug approvals: The Novartis data science and artificial intelligence challenge.


ABSTRACT: We describe a novel collaboration between academia and industry, an in-house data science and artificial intelligence challenge held by Novartis to develop machine-learning models for predicting drug-development outcomes, building upon research at MIT using data from Informa as the starting point. With over 50 cross-functional teams from 25 Novartis offices around the world participating in the challenge, the domain expertise of these Novartis researchers was leveraged to create predictive models with greater sophistication. Ultimately, two winning teams developed models that outperformed the baseline MIT model-areas under the curve of 0.88 and 0.84 versus 0.78, respectively-through state-of-the-art machine-learning algorithms and the use of newly incorporated features and data. In addition to validating the variables shown to be associated with drug approval in the earlier MIT study, the challenge also provided new insights into the drivers of drug-development success and failure.

SUBMITTER: Siah KW 

PROVIDER: S-EPMC8369231 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications

Predicting drug approvals: The Novartis data science and artificial intelligence challenge.

Siah Kien Wei KW   Kelley Nicholas W NW   Ballerstedt Steffen S   Holzhauer Björn B   Lyu Tianmeng T   Mettler David D   Sun Sophie S   Wandel Simon S   Zhong Yang Y   Zhou Bin B   Pan Shifeng S   Zhou Yingyao Y   Lo Andrew W AW  

Patterns (New York, N.Y.) 20210721 8


We describe a novel collaboration between academia and industry, an in-house data science and artificial intelligence challenge held by Novartis to develop machine-learning models for predicting drug-development outcomes, building upon research at MIT using data from Informa as the starting point. With over 50 cross-functional teams from 25 Novartis offices around the world participating in the challenge, the domain expertise of these Novartis researchers was leveraged to create predictive model  ...[more]

Similar Datasets

| S-EPMC10529864 | biostudies-literature
2024-02-15 | GSE228560 | GEO
| S-EPMC8626864 | biostudies-literature
| S-EPMC10114387 | biostudies-literature
| S-EPMC9010092 | biostudies-literature
| S-EPMC6550247 | biostudies-literature
| S-EPMC11392928 | biostudies-literature
| S-EPMC8726033 | biostudies-literature
| S-EPMC9741582 | biostudies-literature
| S-EPMC10990247 | biostudies-literature