Poliovirus Vaccination Induces a Humoral Immune Response That Cross Reacts With SARS-CoV-2.

ABSTRACT: Background: Millions have been exposed to SARS-CoV-2, but the severity of resultant infections has varied among adults and children, with adults presenting more serious symptomatic cases. Children may possess an immunity that adults lack, possibly from childhood vaccinations. This retrospective study suggests immunization against the poliovirus may provide an immunity to SARS-CoV-2. Methods: Publicly available data were analyzed for possible correlations between national median ages and epidemiological outbreak patterns across 100 countries. Sera from 204 adults and children, who were immunized with the poliovirus vaccine, were analyzed using an enzyme-linked immunosorbent assay. The effects of polio-immune serum on SARS-CoV-2-induced cytopathology in cell culture were then e

SUBMITTER: Comunale BA 

PROVIDER: S-EPMC8369257 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature