The physiological effects of cardiac resynchronization therapy on aortic and pulmonary flow and dynamic and static components of systemic impedance.

ABSTRACT:

Background

Patients who improve following cardiac resynchronization therapy (CRT) have left ventricular (LV) remodeling and improved cardiac output (CO). Effects on the systemic circulation are unknown.

Objective

To explore the effects of CRT on aortic and pulmonary blood flow and systemic afterload.

Methods

At CRT implant patients underwent a noninvasive assessment of central hemodynamics, including wave intensity analysis (n = 28). This was repeated at 6 months after CRT. A subsample (n = 11) underwent an invasive electrophysiological and hemodynamic assessment immediately following CRT. CRT response was defined as reduction in LV end-systolic volume ≥15% at 6 months.

Results

In CRT responders (75% of those in the noninvasive arm), there was a significant inc

SUBMITTER: Sidhu BS 

PROVIDER: S-EPMC8369303 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature