Birch allergen challenges in allergic conjunctivitis using standard conjunctival allergen challenge and environmental exposure chamber.

ABSTRACT:

Background

Environmental exposure chambers (EECs) have been used extensively to study allergic rhinoconjunctivitis. Few studies have been published using EECs in conjunctivitis only, and none have used conjunctival allergen challenge as a selection criterion. The present study validated ALYATEC EEC in allergic conjunctivitis to birch pollen.

Methods

Sixteen patients with a positive conjunctival allergen challenge (CAC) were exposed to 60 ng/m³ of Bet v 1 in an EEC on two consecutive days for a maximum of 4 h to validate EEC exposure to birch. Reproducibility was tested among seven of the patients. A conjunctival positive scoring during the CAC and the EEC exposure was defined as a Total Ocular Symptom Score (TOSS) ≥ 5.

Results

Fifty percent of patients had

SUBMITTER: Gherasim A 

PROVIDER: S-EPMC8369317 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature