Identification of tumor antigens and immune subtypes in lower grade gliomas for mRNA vaccine development.

ABSTRACT:

Background

As an important part of tumor immunotherapy for adjunct, therapeutic tumor vaccines have been effective against multiple solid cancers, while their efficacy against lower grade glioma (LGG) remains undefined. Immunophenotyping of tumors is an essential tool to evaluate the immune function of patients with immunodeficiency or autoimmunity. Therefore, this study aims to find the potential tumor antigen of LGG and identify the suitable population for cancer vaccination based on the immune landscape.

Method

The genomic and clinical data of 529 patients with LGG were obtained from TCGA, the mRNA_seq data of normal brain tissue were downloaded from GTEx. Differential expression gene and mutation analysis were performed to screen out potential antigens, K-M curves were c

SUBMITTER: Ye L 

PROVIDER: S-EPMC8369324 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature