Identification of Biomarkers for Cervical Cancer Radiotherapy Resistance Based on RNA Sequencing Data.

ABSTRACT: Cervical cancer as a common gynecological malignancy threatens the health and lives of women. Resistance to radiotherapy is the primary cause of treatment failure and is mainly related to difference in the inherent vulnerability of tumors after radiotherapy. Here, we investigated signature genes associated with poor response to radiotherapy by analyzing an independent cervical cancer dataset from the Gene Expression Omnibus, including pre-irradiation and mid-irradiation information. A total of 316 differentially expressed genes were significantly identified. The correlations between these genes were investigated through the Pearson correlation analysis. Subsequently, random forest model was used in determining cancer-related genes, and all genes were ranked by random forest scoring. The to

SUBMITTER: Feng Y 

PROVIDER: S-EPMC8369412 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature