SULT genetic polymorphisms: physiological, pharmacological and clinical implications.

ABSTRACT:

Introduction

Cytosolic sulfotransferases (SULTs)-mediated sulfation is critically involved in the metabolism of key endogenous compounds, such as catecholamines and thyroid/steroid hormones, as well as a variety of drugs and other xenobiotics. Studies performed in the past three decades have yielded a good understanding about the enzymology of the SULTs and their structural biology, phylogenetic relationships, tissue/organ-specific/developmental expression, as well as the regulation of the SULT gene expression. An emerging area is related to the functional impact of the SULT genetic polymorphisms.

Areas covered

The current review aims to summarize our current knowledge about the above-mentioned aspects of the SULT research. An emphasis is on the information con

SUBMITTER: Kurogi K 

PROVIDER: S-EPMC8369464 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature