Dentate spikes and external control of hippocampal function.

ABSTRACT: Mouse hippocampus CA1 place-cell discharge typically encodes current location, but during slow gamma dominance (SG_dom), when SG oscillations (30-50 Hz) dominate mid-frequency gamma oscillations (70-90 Hz) in CA1 local field potentials, CA1 discharge switches to represent distant recollected locations. We report that dentate spike type 2 (DS_M) events initiated by medial entorhinal cortex II (MECII)→ dentate gyrus (DG) inputs promote SG_dom and change excitation-inhibition coordinated discharge in DG, CA3, and CA1, whereas type 1 (DS_L) events initiated by lateral entorhinal cortex II (LECII)→DG inputs do not. Just before SG_dom, LECII-originating SG oscillations in DG and CA3-originating SG oscillations in CA1 phase and frequency synchroni

SUBMITTER: Dvorak D 

PROVIDER: S-EPMC8369486 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature