Presence of human polyomavirus 6 in mutation-specific BRAF inhibitor-induced epithelial proliferations.

ABSTRACT:

Importance

A frequent adverse effect of mutation-specific BRAF inhibitor therapy is the induction of epithelial proliferations including cutaneous squamous cell carcinomas. To date, the only factor identified contributing to their development is the activation of the mitogen-activated signal transduction cascade by mutations in the RAS genes. However, these mutations explain only 60% of the tumors; hence, it is important to identify what is causing the remaining tumors.

Objective

To test for the presence of human papillomaviruses (HPVs) and the recently identified human polyomaviruses (HPyVs), Merkel cell polyomavirus (MCPyV), and trichodysplasia spinulosa-associated polyomavirus (TSPyV), as well as HPyV-6, HPyV-7, HPyV-9, and HPyV-10, in epithelial proliferations occurring

SUBMITTER: Schrama D 

PROVIDER: S-EPMC8369517 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature