A detailed analysis of innate and adaptive immune responsiveness upon infection with Salmonella enterica serotype Enteritidis in young broiler chickens.

ABSTRACT: Salmonella enterica serotype Enteritidis (SE) is a zoonotic pathogen which causes foodborne diseases in humans as well as severe disease symptoms in young chickens. More insight in innate and adaptive immune responses of chickens to SE infection is needed to understand elimination of SE. Seven-day-old broiler chickens were experimentally challenged with SE and numbers and responsiveness of innate and adaptive immune cells as well as antibody titers were assessed. SE was observed in the ileum and spleen of SE-infected chickens at 7 days post-infection (dpi). At 1 dpi numbers of intraepithelial cytotoxic CD8⁺ T cells were significantly increased alongside numerically increased intraepithelial IL-2Rα⁺ and 20E5⁺ natural killer (NK) cells at 1 and 3 dpi. At both

SUBMITTER: Meijerink N 

PROVIDER: S-EPMC8369617 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature