Effects of EFNA1 on cell phenotype and prognosis of esophageal carcinoma.

ABSTRACT:

Background

To investigate the expression and clinical significance of EFNA1 in broad-spectrum tumors, and to evaluate its relationship with prognosis and biological functions of esophageal carcinoma (ESCA).

Methods

EFNA1 expression in various cancers was analyzed according to the data in the TCGA database. The clinical data were integrated, to analyze the relationship with ESCA clinical parameters and prognosis, and EFNA1 expression in ESCA tissue samples was detected by immunohistochemistry (IHC). Based on bioinformatics, the functional background of EFNA1 overexpression was analyzed. EFNA1 knockout cell model was established by EFNA1-shRNA transfecting ESCA cells, and the effect of knocking down EFNA1 on the proliferation of ESCA cells was detected by MTT.

Results

A

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8369630 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature