Influence of miR-221/222 on cardiomyocyte calcium handling and function.

ABSTRACT:

Background

Cardiovascular disease is the leading cause of death worldwide. Cardiac electrical remodeling including altered ion channel expression and imbalance of calcium homeostasis can have detrimental effects on cardiac function. While it has been extensively reported that miR-221/222 are involved in structural remodeling, their role in electrical remodeling still has to be evaluated. We previously reported that subunits of the L-type Ca²⁺ channel (LTCC) are direct targets of miR-221/222. Furthermore, HL-1 cells transfected with miR-221 or -222 mimics showed a reduction in LTCC current density while the voltage-dependence of activation was not altered. The aim of the present study was to determine the influence of miR-221/222 on cardiomyocyte calcium handling and func

SUBMITTER: Knyrim M 

PROVIDER: S-EPMC8369661 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature