Ontology highlight
ABSTRACT:
SUBMITTER: Saha-Shah A
PROVIDER: S-EPMC8369675 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Saha-Shah Anumita A Sun Shuwen S Kong John J Zhong Wendy W Mann Benjamin F BF
ACS pharmacology & translational science 20210620 4
Several PEGylated therapeutic proteins are approved drugs, and more are under development. However, the synthesis and characterization of these bioconjugates, especially heterogeneous mixtures of PEGylated proteins, are challenging. The present study focuses on the development of PEG linkers that can be installed through biocatalytic route and render much simpler and insightful analytical characterization of PEG-protein conjugates. This linker enables traditional peptide mapping assay to determi ...[more]