Fishing for Contact: Modeling Perivascular Glioma Invasion in the Zebrafish Brain.

ABSTRACT: Glioblastoma multiforme (GBM) is a highly invasive, central nervous system (CNS) cancer for which there is no cure. Invading tumor cells evade treatment, limiting the efficacy of the current standard of care regimen. Understanding the underlying invasive behaviors that support tumor growth may allow for generation of novel GBM therapies. Zebrafish (Danio rerio) are attractive for genetics and live imaging and have, in recent years, emerged as a model system suitable for cancer biology research. While other groups have studied CNS tumors using zebrafish, few have concentrated on the invasive behaviors supporting the development of these diseases. Previous studies demonstrated that one of the main mechanisms of GBM invasion is perivascular invasion, i.e., single tumor cell migration a

SUBMITTER: Umans RA 

PROVIDER: S-EPMC8369679 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature