Possible role of HPV/EBV coinfection in anoikis resistance and development in prostate cancer.

ABSTRACT:

Background

This study aimed to evaluate the possible role of human papillomavirus (HPV) and Epstein-Barr virus (EBV) coinfection as an etiological factor for prostate cancer (PCa) development.

Methods

This case-control study was conducted on 67 patients with PCa and 40 control subjects. The expression levels of cellular and viral factors involved in inflammation, tumor progression, and metastasis were quantified, using the enzyme-linked immunosorbent assay (ELISA) and quantitative real-time polymerase chain reaction (qRT-PCR) assay.

Results

The EBV/HPV coinfection was reported in 14.9% of patients in the case group and 7.5% of the control subjects. The high-risk types of HPV, that is, HPV 16 and HPV 18, were responsible for 50 and 30% of HPV/EBV-coinfected PCa cases (

SUBMITTER: Nahand JS 

PROVIDER: S-EPMC8369687 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature