Ontology highlight
ABSTRACT:
SUBMITTER: Truchan NA
PROVIDER: S-EPMC8369690 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Truchan Nathan A NA Fenske Rachel J RJ Sandhu Harpreet K HK Weeks Alicia M AM Patibandla Chinmai C Wancewicz Benjamin B Pabich Samantha S Reuter Austin A Harrington Jeffrey M JM Brill Allison L AL Peter Darby C DC Nall Randall R Daniels Michael M Punt Margaret M Kaiser Cecilia E CE Cox Elizabeth D ED Ge Ying Y Davis Dawn B DB Kimple Michelle E ME
ACS pharmacology & translational science 20210616 4
Elevated islet production of prostaglandin E<sub>2</sub> (PGE<sub>2</sub>), an arachidonic acid metabolite, and expression of prostaglandin E<sub>2</sub> receptor subtype EP3 (EP3) are well-known contributors to the β-cell dysfunction of type 2 diabetes (T2D). Yet, many of the same pathophysiological conditions exist in obesity, and little is known about how the PGE<sub>2</sub> production and signaling pathway influences nondiabetic β-cell function. In this work, plasma arachidonic acid and PGE< ...[more]