Alpha-synuclein activates the classical complement pathway and mediates complement-dependent cell toxicity.

ABSTRACT:

Background

Synucleinopathies are characterized by neurodegeneration and deposition of the presynaptic protein α-synuclein in pathological protein inclusions. Growing evidence suggests the complement system not only has physiological functions in the central nervous system, but also is involved in mediating the pathological loss of synapses in Alzheimer's disease. However, it is not established whether the complement system has a similar role in the diseases Parkinson's disease, Dementia with Lewy bodies, and multiple system atrophy (MSA) that are associated with α-synuclein aggregate pathology.

Methods

To investigate if the complement system has a pathological role in synucleinopathies, we assessed the effect of the complement system on the viability of an α-synuclein expres

SUBMITTER: Gregersen E 

PROVIDER: S-EPMC8369722 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature