Lipoprotein lipase hydrolysis products induce pro-inflammatory cytokine expression in triple-negative breast cancer cells.

ABSTRACT:

Objectives

Breast cancer cell growth and proliferation requires lipids for energy production, cell membrane synthesis, or as signaling molecules. Lipids can be delivered to cells by lipoprotein lipase (LPL), an extracellular lipase that hydrolyzes triacylglycerols and phospholipids from lipoproteins, that is expressed by adipose tissue and some breast cancer cell lines. Studies have shown that lipoprotein hydrolysis products induce pro-inflammatory cytokine secretion by endothelial cells. Thus, our objective was to determine if hydrolysis products generated by LPL from total lipoproteins can also promote pro-inflammatory cytokine secretion from breast cancer cells.

Results

Using cytokine arrays, we found that MDA-MB-231 cells increased secretion of seven cytokines in respons

SUBMITTER: Tobin AJ 

PROVIDER: S-EPMC8369739 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature