Experimental Babesia rossi infection induces hemolytic, metabolic, and viral response pathways in the canine host.

ABSTRACT:

Background

Babesia rossi is a leading cause of morbidity and mortality among the canine population of sub-Saharan Africa, but pathogenesis remains poorly understood. Previous studies of B. rossi infection were derived from clinical cases, in which neither the onset of infection nor the infectious inoculum was known. Here, we performed controlled B. rossi inoculations in canines and evaluated disease progression through clinical tests and whole blood transcriptomic profiling.

Results

Two subjects were administered a low inoculum (10⁴ parasites) while three received a high (10⁸ parasites). Subjects were monitored for 8 consecutive days; anti-parasite treatment with diminazene aceturate was administered on day 4. Blood was drawn prior to inoculation as wel

SUBMITTER: Smith RL 

PROVIDER: S-EPMC8369750 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature