Metabolic convergence on lipogenesis in RAS, BCR-ABL, and MYC-driven lymphoid malignancies.

ABSTRACT:

Background

Metabolic reprogramming is a central feature in many cancer subtypes and a hallmark of cancer. Many therapeutic strategies attempt to exploit this feature, often having unintended side effects on normal metabolic programs and limited efficacy due to integrative nature of metabolic substrate sourcing. Although the initiating oncogenic lesion may vary, tumor cells in lymphoid malignancies often share similar environments and potentially similar metabolic profiles. We examined cells from mouse models of MYC-, RAS-, and BCR-ABL-driven lymphoid malignancies and find a convergence on de novo lipogenesis. We explore the potential role of MYC in mediating lipogenesis by ¹³C glucose tracing and untargeted metabolic profiling. Inhibition of lipogenesis leads to cell dea

SUBMITTER: Liefwalker DF 

PROVIDER: S-EPMC8369789 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature