Identification of PLA2G7 as a novel biomarker of diffuse large B cell lymphoma.

ABSTRACT:

Background

Diffuse large B-cell lymphoma is the most common form of non-Hodgkin lymphoma globally, and patients with relapsed or refractory DLBCL typically experience poor long-term outcomes.

Methods

Differentially expressed genes associated with DLBCL were identified using two GEO datasets in an effort to detect novel diagnostic or prognostic biomarkers of this cancer type, after which receiver operating characteristic curve analyses were conducted. Genes associated with DLBCL patient prognosis were additionally identified via WCGNA analyses of the TCGA database. The expression of PLA2G7 in DLBCL patient clinical samples was further assessed, and the functional role of this gene in DLBCL was assessed through in vitro and bioinformatics analyses.

Results

DLBCL-related

SUBMITTER: Zheng W 

PROVIDER: S-EPMC8369790 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature