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Presence of a SARS-CoV-2 Protein Enhances Amyloid Formation of Serum Amyloid A.

ABSTRACT: A marker for the severeness and disease progress of COVID-19 is overexpression of serum amyloid A (SAA) to levels that in other diseases are associated with a risk for SAA amyloidosis. To understand whether SAA amyloidosis could also be a long-term risk of SARS-CoV-2 infections, we have used long all-atom molecular dynamic simulations to study the effect of a SARS-CoV-2 protein segment on SAA amyloid formation. Sampling over 40 μs, we find that the presence of the nine-residue segment SK9, located at the C-terminus of the envelope protein, increases the propensity for SAA fibril formation by three mechanisms: it reduces the stability of the lipid-transporting hexamer shifting the equilibrium toward monomers, it increases the frequency of aggregation-prone configurations in the resulting chains, and it raises the stability of SAA fibrils. Our results therefore suggest that SAA amyloidosis and related pathologies may be a long-term risk of SARS-CoV-2 infections.

SUBMITTER: Jana AK

PROVIDER: S-EPMC8369982 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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Presence of a SARS-CoV-2 Protein Enhances Amyloid Formation of Serum Amyloid A.

Jana Asis K AK Greenwood Augustus B AB Hansmann Ulrich H E UHE

The journal of physical chemistry. B 20210809 32

A marker for the severeness and disease progress of COVID-19 is overexpression of serum amyloid A (SAA) to levels that in other diseases are associated with a risk for SAA amyloidosis. To understand whether SAA amyloidosis could also be a long-term risk of SARS-CoV-2 infections, we have used long all-atom molecular dynamic simulations to study the effect of a SARS-CoV-2 protein segment on SAA amyloid formation. Sampling over 40 μs, we find that the presence of the nine-residue segment SK9, locat ...[more]

PMID: 34370466

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Presence of a SARS-COV-2 protein enhances Amyloid Formation of Serum Amyloid A.

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