Risk factors for vertical transmission of Chagas disease: A systematic review and meta-analysis.

ABSTRACT:

Background

Vertical transmission of Trypanosoma cruzi infection from mother to infant accounts for a growing proportion of new Chagas disease cases. However, no systematic reviews of risk factors for T. cruzi vertical transmission have been performed.

Methods

We performed a systematic review of the literature in PubMed, LILACS, and Embase databases, following PRISMA guidelines. Studies were not excluded based on language, country of origin, or publication date.

Results

Our literature review yielded 27 relevant studies examining a wide variety of risk factors, including maternal age, parasitic load, immunologic factors and vector exposure. Several studies suggested that mothers with higher parasitic loads may have a greater risk of vertical transmission. A meta-analysi

SUBMITTER: Klein MD 

PROVIDER: S-EPMC8370023 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature