Serum GFAP for stroke diagnosis in regions with limited access to brain imaging (BE FAST India).

ABSTRACT:

Introduction

Despite a high burden of stroke, access to rapid brain imaging is limited in many middle- and low-income countries. Previous studies have described the astroglial protein GFAP (glial fibrillary acidic protein) as a biomarker of intracerebral hemorrhage. The aim of this study was to test the diagnostic accuracy of GFAP for ruling out intracranial hemorrhage in a prospective cohort of Indian stroke patients.

Patients and methods

This study was conducted in an Indian tertiary hospital (Christian Medical College, Ludhiana). Patients with symptoms suggestive of acute stroke admitted within 12 h of symptom onset were enrolled. Blood samples were collected at hospital admission. Single Molecule Array technology was used for determining serum GFAP concentrations.

Res

SUBMITTER: Kalra LP 

PROVIDER: S-EPMC8370074 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature