Bioinformatic Analysis for Potential Biomarkers and Therapeutic Targets of T2DM-related MI.

ABSTRACT:

Background

Type 2 diabetes mellitus (T2DM), a major risk factor of coronary heart disease, is associated with an approximately twofold increase in the risk of myocardial infarction (MI). We studied co-expressed genes to demonstrate relationships between DM and MI and revealed the potential biomarkers and therapeutic targets of T2DM-related MI.

Methods

DM and MI-related differentially expressed genes (DEGs) were identified by bioinformatic analysis, Gene Expression Omnibus (GEO) datasets GSE42148 and GSE61144 of MI patients, and the normal control and GSE26168 and GSE15932 of DM patients and normal controls, respectively. Further target prediction and network analysis method were used to detect protein-protein interaction (PPI) networks, gene ontology (GO) terms, and pathway

SUBMITTER: Li C 

PROVIDER: S-EPMC8370113 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature