Exploring the Global Spread of Klebsiella grimontii Isolates Possessing bla_VIM-1 and mcr-9.

ABSTRACT: The spread of plasmid-mediated carbapenemases within Klebsiella oxytoca is well-documented. In contrast, data concerning the closely related species Klebsiella grimontii are scarce. In fact, despite the recent report of the first bla_KPC-2-producing K. grimontii, nothing is known about its clonality and antibiotic resistance patterns. In a retrospective search in our collection, we identified 2 bla_VIM-positive K. oxytoca strains. Whole-genome sequencing with both Illumina and Nanopore indicated that our strains actually belonged to K. grimontii and were of sequence type 172 (ST172) and ST189. Moreover, the two strains were associated with 297-kb IncHI2/HI2A-pST1 and 90.6-kb IncFII(Yp) plasmids carrying bla_VIM-1 together wit

SUBMITTER: Campos-Madueno EI 

PROVIDER: S-EPMC8370233 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature