Multiresistance to Nonazole Fungicides in Aspergillus fumigatus TR₃₄/L98H Azole-Resistant Isolates.

ABSTRACT: Drug resistance is a worldwide problem affecting all pathogens. The human fungal pathogen Aspergillus fumigatus coexists in the environment with other fungi targeted by crop protection compounds, being unintentionally exposed to the selective pressure of multiple antifungal classes and leading to the selection of resistant strains. A. fumigatus azole-resistant isolates are emerging in both clinical and environmental settings. Since their approval, azole drugs have dominated clinical treatment for aspergillosis infections and the agriculture fungicide market. However, other antifungal classes are used for crop protection, including benzimidazoles (methyl benzimidazole carbamates [MBCs]), strobilurins (quinolone oxidation inhibitors [QoIs]), and succinate dehydrogenase inhibitors (SDHIs). Mu

SUBMITTER: Gonzalez-Jimenez I 

PROVIDER: S-EPMC8370240 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature