Measuring Changes in Electrical Impedance During Cell-Mediated Mineralization.

ABSTRACT: Background: The fundamental electrical properties of bone have been attributed to the organic collagen and the inorganic mineral component; however, contributions of individual components within bone tissue toward the measured electrical properties are not known. In our study, we investigated the electrical properties of cell-mediated mineral deposition process and compared our results with cell-free mineralization. Materials and Methods: Saos-2 cells encapsulated within gelatin methacrylate (GelMA) hydrogels were chemically stimulated in osteogenic medium for a period of 4 weeks. The morphology, composition, and mechanical properties of the mineralized constructs were characterized using bright-field imaging, scanning electron microscopy (SEM) energy-dispersive

SUBMITTER: Ramos R 

PROVIDER: S-EPMC8370274 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature