Extracellular K+ Dampens T Cell Functions: Implications for Immune Suppression in the Tumor Microenvironment.
Ontology highlight
ABSTRACT: Background: Dying tumor cells release intracellular potassium (K+), raising extracellular K+ ([K+]e) in the tumor microenvironment (TME) to 40-50 mM (high-[K+]e). Here, we investigated the effect of high-[K+]e on T cell functions. Materials and Methods: Functional impacts of high-[K+]e on human T cells were determined by cellular, molecular, and imaging assays. Results: Exposure to high-[K+]e suppressed the proliferation of central memory and effector memory T cells, while T memory stem cells were unaffected. High-[K+]e inhibited T cell cytokine production and dampened antitumor cytotoxicity, by m
SUBMITTER: Ong ST
PROVIDER: S-EPMC8370284 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
ACCESS DATA
