Substrate-Dependent Galvanotaxis of Directly Reprogrammed Human Neural Precursor Cells.

ABSTRACT: Background: Neural precursor cells (NPCs) hold great promise for neural repair. Endogenous NPCs, found in the subventricular zone of the adult brain, proliferate and migrate toward lesion sites; however, it is not sufficient for neural repair. NPCs are electrosensitive cells that undergo directed migration in an electric field (EF). Here, we examined the EF-induced migration of a clinically relevant human NPC population. Materials & Methods: We examined the effects of different substrates and microenvironments on human NPC galvanotaxis. Results: Human NPCs increased their migration speed in the presence of an EF, and the direction of migration (anodal vs. cathodal) varied between substrates. The secretome and extracellular pH were not significant f

SUBMITTER: Ahmed U 

PROVIDER: S-EPMC8370329 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature