Physiological Effects of the Electrogenic Current Generated by the Na⁺/K⁺ Pump in Mammalian Articular Chondrocytes.

ABSTRACT: Background: Although the chondrocyte is a nonexcitable cell, there is strong interest in gaining detailed knowledge of its ion pumps, channels, exchangers, and transporters. In combination, these transport mechanisms set the resting potential, regulate cell volume, and strongly modulate responses of the chondrocyte to endocrine agents and physicochemical alterations in the surrounding extracellular microenvironment. Materials and Methods: Mathematical modeling was used to assess the functional roles of energy-requiring active transport, the Na⁺/K⁺ pump, in chondrocytes. Results: Our findings illustrate plausible physiological roles for the Na⁺/K⁺ pump in regulating the resting membrane potential and sugge

SUBMITTER: Maleckar MM 

PROVIDER: S-EPMC8370340 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature