Early-life Farm Exposure and Ovarian Reserve in a US Cohort of Women.

ABSTRACT:

Background

In a previous exploratory study, we reported lower concentrations of the ovarian reserve biomarker anti-Müllerian hormone (AMH) in adulthood with prenatal farm exposure. We now examine this association as well as childhood farm exposure using enrollment data from the Sister Study, a large US cohort of women.

Methods

We collected prenatal and childhood farm exposure data by questionnaire and telephone interview. However, serum AMH data were available only for a nested subset: premenopausal women ages 35-54 subsequently diagnosed with breast cancer (n = 418 cases) and their matched controls (n = 866). To avoid potential bias from restricting analyses to only premenopausal controls, we leveraged the available cohort data. We used data from both premenopausal cases an

SUBMITTER: Upson K 

PROVIDER: S-EPMC8370468 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature