Direct Current Electric Stimulation Alters the Frequency and the Distribution of Mitotic Cells in Planarians.

ABSTRACT: Background: The use of direct current electric stimulation (DCS) is an effective strategy to treat disease and enhance body functionality. Thus, treatment with DCS is an attractive biomedical alternative, but the molecular underpinnings remain mostly unknown. The lack of experimental models to dissect the effects of DCS from molecular to organismal levels is an important caveat. Here, we introduce the planarian flatworm Schmidtea mediterranea as a tractable organism for in vivo studies of DCS. We developed an experimental method that facilitates the application of direct current electrical stimulation to the whole planarian body (pDCS). Materials and Methods: Planarian immobilization was achieved by combining treatment with anesthesia, agar embeddi

SUBMITTER: Davidian D 

PROVIDER: S-EPMC8370485 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature