Antibodies against type I interferon: detection and association with severe clinical outcome in COVID-19 patients.

ABSTRACT:

Objectives

Impairment of type I interferon (IFN-I) immunity has been reported in critically ill COVID-19 patients. This defect can be explained in a subset of patients by the presence of circulating autoantibodies (auto-Abs) against IFN-I. We set out to improve the detection and the quantification of IFN-I auto-Abs in a cohort of critically ill COVID-19 patients, in order to better evaluate the prevalence of these Abs as the pandemic progresses, and how they correlate with the clinical course of the disease.

Methods

The concentration of anti-IFN-α₂ Abs was determined in the serum of 84 critically ill COVID-19 patients who were admitted to ICU in Hospices Civils de Lyon, France, using a commercially available kit (Thermo Fisher, Catalog #BMS217).

R

SUBMITTER: Goncalves D 

PROVIDER: S-EPMC8370568 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature