Genetic Variation of Inflammatory Genes to Ischemic Stroke Risk in a Chinese Han Population.

ABSTRACT:

Background

Inflammation proteins play an important role in stroke occurrence. IL1A, IL1B, PTGS2, MMP2, and MMP9 were the mediators involved in the immune response, and the association of these genetic variations with ischemic stroke (IS) risk was still unclear.

Methods

To investigate the susceptibility of genetic variations of IL1A, IL1B, PTGS2, MMP2, and MMP9 to IS risk, we performed a case-control study involving 299 patients and 300 controls in a Chinese population. Thirteen genetic variations of investigated genes of all participants were genotyped using an improved multiplex ligase detection-reaction technique.

Results

No SNP in all genes showed an association with overall IS. However, in subgroup analysis, PTGS2 rs689466 (domin

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC8370589 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature