Ontology highlight
ABSTRACT:
SUBMITTER: Niehrs A
PROVIDER: S-EPMC8370669 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Niehrs Annika A Garcia-Beltran Wilfredo F WF Norman Paul J PJ Watson Gabrielle M GM Hölzemer Angelique A Chapel Anaïs A Richert Laura L Pommerening-Röser Andreas A Körner Christian C Ozawa Mikki M Martrus Glòria G Rossjohn Jamie J Lee Jar-How JH Berry Richard R Carrington Mary M Altfeld Marcus M
Nature immunology 20190729 9
Natural killer (NK) cells can recognize virus-infected and stressed cells<sup>1</sup> using activating and inhibitory receptors, many of which interact with HLA class I. Although early studies also suggested a functional impact of HLA class II on NK cell activity<sup>2,3</sup>, the NK cell receptors that specifically recognize HLA class II molecules have never been identified. We investigated whether two major families of NK cell receptors, killer-cell immunoglobulin-like receptors (KIRs) and na ...[more]