A subset of HLA-DP molecules serve as ligands for the natural cytotoxicity receptor NKp44.

ABSTRACT: Natural killer (NK) cells can recognize virus-infected and stressed cells¹ using activating and inhibitory receptors, many of which interact with HLA class I. Although early studies also suggested a functional impact of HLA class II on NK cell activity^2,3, the NK cell receptors that specifically recognize HLA class II molecules have never been identified. We investigated whether two major families of NK cell receptors, killer-cell immunoglobulin-like receptors (KIRs) and natural cytotoxicity receptors (NCRs), contained receptors that bound to HLA class II, and identified a direct interaction between the NK cell receptor NKp44 and a subset of HLA-DP molecules, including HLA-DP401, one of the most frequent class II allotypes in white populations⁴. Using NKp44

SUBMITTER: Niehrs A 

PROVIDER: S-EPMC8370669 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature